phenobarbital raises toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. CYP3A4 inducers could enhance the metabolism of ifosfamide to its active alkylating metabolites.

Hypnotic doses of barbiturates will not surface to impair uterine action noticeably all through labor. Complete anesthetic doses of barbiturates decrease the pressure and frequency of uterine contractions. Administration of sedative-hypnotic barbiturates for the mom through labor may perhaps result in respiratory melancholy from the newborn.

This isn't a whole listing of achievable Unwanted effects. In case you notice other results not shown earlier mentioned, contact your medical doctor or pharmacist.

Keep track of Carefully (three)phenobarbital will minimize the level or influence of diazepam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Solid or average CYP3A4 inducers may perhaps improve fee of diazepam elimination; consequently, efficacy of diazepam might be lowered.

Comment: Barbiturates may maximize adverse consequences, together with respiratory melancholy, made by harmful doses of TCAs. With therapeutic doses of TCAs, barbiturates maximize metabolism and reduce blood concentrations of TCAs.

Dialysis will enhance the level of removing of barbiturates from your body fluids. Antibiotics can be necessary to Handle pulmonary problems.

The systemic effects of exogenous and endogenous corticosteroids may very well be diminished by phenobarbital. So, this product or service must be administered with warning to sufferers with borderline hypoadrenal function, regardless of whether it is of pituitary or of Principal adrenal origin.

The subsequent adverse reactions as well as their incidence were being more info compiled from surveillance of Many hospitalized people who gained barbiturates.

Phenobarbital is contraindicated in individuals who're hypersensitive to barbiturates, in sufferers using a history of manifest or latent porphyria, As well as in patients with marked impairment of liver purpose or respiratory illness wherein dyspnea or obstruction is obvious.

Abrupt cessation immediately after extended use inside a one who is dependent on the drug may well bring about withdrawal signs and symptoms, like delirium, convulsions, And perhaps Demise. Barbiturates need to be withdrawn steadily from any individual acknowledged being having too much doses over prolonged periods of time (see DRUG ABUSE AND DEPENDENCE).

Dosage really should be diminished inside the aged or debilitated for the reason that these individuals might be a lot more sensitive to barbiturates. Dosage should be diminished for sufferers with impaired renal purpose or hepatic sickness.

The usage of barbiturates carries with it an connected chance of psychological and/or Bodily dependence. The patient ought to be warned towards growing the dose from the drug with out consulting a physician.

All barbiturates show anticonvulsant activity in anesthetic doses; nonetheless, from the drugs During this class, only phenobarbital, mephobarbital, and metharbital are effective as oral anticonvulsants in subhypnotic doses.

Not often, the use of barbiturates ends in localized or subtle myalgic, neuralgic, or arthritic soreness, particularly in psychoneurotic individuals with sleeplessness. The pain may well seem in paroxysms, is most rigorous inside the early early morning hrs, and is most frequently located in the area of the neck, shoulder girdle, and upper limbs. Signs or symptoms could very last for times after the drug is discontinued.